Thanks. There are two strengths of xylometazoline nose drops. A nasal spray is available for adults and for children over 12 years of age. Astepro (azelastine) is an antihistamine nasal spray that can help with allergy or nasal symptoms. Nasal sprays became over-the-counter drugs in 1975 after initial success as prescription medications. Oxymetazoline and xylometazoline are locally viable and coordinate acting medications that calm nasal clog. Afrin (oxymetazoline) clears stuffy noses, but can worsen your congestion if it is … The active ingredients in these products – ephedrine, epinephrine, naphazoline, oxymetazoline, phenylephrine, pseudoephedrine, tetrahydrozoline, and xylometazoline – are low risk, with one caveat: I would avoid using pseudoephedrine in the first trimester … Most nasal sprays contain Oxymetazoline hydrochloride which was developed from xylometazoline at E. Merck Darmastadt by Fruhstorfer in 1961. [2] Use is also not recommended in those less than three months of age and some say not less than 6 years of age. Xylometazoline: A nasal vasoconstricting decongestant tranquilize which acts by official to indistinguishable receptors from adrenaline. For those people who have used decongestant nasal sprays with oxymetazoline (Afrin) or xylometazoline (Otrivine), what's the difference in duration of effect and also, which one gives the most rebound swelling when using for multiple days? It is connected as a spray or as drops into the nose to ease aggravation and clog of the nasal paths. Rhinocort Aqua (Budesonide) is a steroid nasal spray that works best when used regularly for your nasal allergy symptoms. Xylometazoline, also spelled xylomethazoline, is a medication used to reduce symptoms of nasal congestion, allergic rhinitis, and sinusitis. There is an adult strength of 0.1%, and a child strength of 0.05% which is suitable for children aged 6 years or over. BackgroundOxymetazoline and xylometazoline are locally effective and direct acting drugs that relieve nasal congestion. Oxymetazoline is a topical decongestant, used in the form of oxymetazoline hydrochloride.It was developed from xylometazoline at E. Merck Darmstadt by Fruhstorfer in 1961. The aim of this study was to objectively determine and compare the decongestive effects of oxymetazoline and xylometazoline in healthy subjects.MethodsThe study population comprised thirty healthy adults. I only have used a phenylefrine nasal spray and it only works for like 3 hours. Problems occur if you are tempted to spray a little more or a little longer, in spite of the instructions, which say ten days max. The active substances xylometazoline and oxymetazoline cause blood vessels in the nasal mucosa to contract, which allows freer breathing. Afrin (oxymetazoline) clears stuffy noses, but can worsen your congestion if it is used more frequently than 3 days in a row. 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